Overtone Analytics

Case studies

Casgevy: How to use the word "cure"

Roctavian: The words around a one-time cure

Timeline of how the word "cure" was used around Casgevy, from the first lab finding to 2026

The word didn't get louder. It got narrower, then defined, then dropped.

Read the case

Roctavian: The words around a one-time cure

Timeline of Roctavian from the 2017 "set to cure" headline to the 2026 withdrawal

"Set to cure" arrived with 13 patients and a year of data. Nine years later, the therapy is leaving the market.

Read the case

Altuviiio and fitusiran: The words around therapies you keep taking

Timeline of Altuviiio and fitusiran milestones and naming moments, 2017 to 2026

Two hemophilia therapies that never promised a cure, and what a claim you can check is worth.

Read the case

How a finding grows on its way out of the lab

Altuviiio and fitusiran: The words around therapies you keep taking

Diagram: a finding grows larger at each step, from grant to paper to press release to AI summary

Hype doesn't start in the newsroom. It starts in the grant application.

Read the case

Overtone Analytics, LLC is an early-stage research venture focused on the dynamics of biomedical communication, studying how the language used to describe scientific findings evolves from the lab to publication and then to the clinic. Through Overtone Interviews, we engage with researchers to explore how they initially articulated their work and how that language transformed over time. Our goal is to develop advanced analytics tools that can effectively measure these shifts across the research pipeline, leveraging language intelligence to enhance our understanding of scientific discourse.